Let's analyze the pattern in the given series:
12 = 5 * 2 + 2
26 = 12 * 2 + 2
54 = 26 * 2 + 2
110 = 54 * 2 + 2
The pattern is to multiply the previous number by 2 and then add 2.
Following this pattern, the next number would be:
110 * 2 + 2 = 220 + 2 = 222
Therefore, the next number in the series is 222.